More recently, he has investigated the immune activities of HMGB1, a nuclear protein with alarmin activity, as well as microparticles. He was focusing on the pathogenesis of systemic lupus erythematosus (SLE) and the immunological properties of nuclear macromolecules, including DNA.
He has conducted basic and translational research in the field of autoimmunity. He served as Chief of Rheumatology and Immunology at Duke from 2003-2008.
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